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A study employing high-resolution immunocytochemistry at both light and electron microscopic levels in rodents has demonstrated that neurons efficiently uptake lactate via monocarboxylate transporter 2 (MCT2), a high-affinity transporter localized at postsynaptic densities to facilitate lactate import from astrocyte-released sources (Bergersen, 2007) and subsequently convert it to pyruvate via lactate dehydrogenase isotype 1
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They have higher levels of specific proteins [such as heat shock protein 70 (HSP 70), tetraspanins (CD9, CD 63, CD 81, and CD 82), ALG-2-interacting protein X (ALIX), tumor susceptibility gene 101 (TSG101)] and lipids [such as flotillin and glycosylphosphatidylinositol-anchored protein (LBPA)] (20–22)
